A proactive and entrepreneurial international market approach: Some evidence in the Portuguese hotel sector

Internationalization is a process of such complexity that its explanation, in terms of one single theoretical perspective is difficult. Drawing on a comprehensive multi-case study, this doctoral thesis explores the influence environmental and organizational stimuli as determinants of Portuguese hotel firms’ international engagement. It also proposes to understand the linkage between the antecedent firm motivational stimuli factors with, time of entry, market selection and entry mode strategies. The strategy regarding the epistemological position is via a deductive research approach, where is identify, and tests, in the field, the propositions initially proposed, for further development. A previously used framework was adopted to structure the factors involved, thus ensuring that all comprehensive evidence was obtained through empirical research. Having its foundations in Barney´s resource-based theory and International Entrepreneurship principles within Dunning's eclectic model determinants, this model sheds light on firm´s resources and competences as determinants factors for the decision to go abroad, pointing the ownership and location advantages as main determinants factors of internationalization strategy decisions. Due to the limited number of the total population, a non-probability purposive sampling method was adopted. This study is mainly based on semi-structured interviews to top level managers, responsible for the internationalization process and supplemented by confirmatory questionnaires, memos, press releases, media articles and in-situ observations. Accordingly, a within and cross-case analysis was applied for the deduction of facts. From the data analysis, it is seen that that the internal competences and the firm’s managerial entrepreneurial profile were important stimuli for the Potuguese hotel grups becoming involved in international activities. Accordingly, it was found that the combination of proactive, internal and external, stimuli drives initially, the Portuguese hotel groups to international market. It was the junction of these proactive stimuli, within an entrepreneurial vision from managers that triggered the process of internationalization. An evolution of the nature´s motivational stimuli was also found given the level of international engagement and the development of market environment. Hence, from an opportunistic market seeker motivation, the Portuguese hotel firms turned to efficiency seeking motivation, less based on tacit competences exploitation and more focused in network and coordination competences, emerging a systematic market exploitation taking into account the new profile of demand and firm growth ambitions in international market. It was also found that, in the early stages of international engagement a positive linkage between the firm proactive stimuli factors and the Portuguese firm international strategies. From the contributions that emerged from the work, stood out, in the theoretical field the achievement of a deeper knowledge, of the motivational, and stimuli factor, on the internationalization process and the importance of manager´s proactive attitude as key determinant of the linkage between the company's competitive advantages and strategies of internationalization. Concerning the practical implications, a better understanding of the key resources and competencies to exploring market opportunities, can be an aid to hotel firms companies that are considering expanding to other markets, thus, preventing the dispersion and improper use of scarce firm assets.A internacionalização é um processo de tal complexidade que a sua explicação é difícil em termos de uma única perspetiva teórica. Baseado num estudo multi-caso, esta tese de doutoramento explora a influência dos estímulos ambientais e organizacionais como determinantes do envolvimento das empresas hoteleiras portuguesas no mercado internacional. Também propõe compreender a ligação entre os estímulos motivacionais e as estratégias relativas ao processo de internacionalização. A abordagem epistemológica do estudo é maioritariamente dedutiva, onde o pesquisador identifica e testa no campo, as proposições inicialmente propostas. Assim e em conformidade, foi adotada uma matriz previamente estruturada, garantindo que todas as variáveis do modelo fossem obtidas através de uma pesquisa empírica. Tendo nos seus fundamentos a Teoria Baseada nos Recursos de Barney, integrando os princípios do Empreendedorismo Internacional e utilizando as determinantes do modelo eclético de Dunning para explicar as estratégias de internacionalização, este modelo lança luz sobre os recursos e competências da empresa como determinantes na decisão de sair para o estrangeiro, apontando as vantagens de propriedade e de localização, como principais fatores decisivos nas estratégias de internacionalização. Devido ao número limitado da população, foi adotado um método de amostragem nãoprobabilístico. A recolha de dados, foi baseada em entrevistas semiestruturadas a gestores e responsáveis pelo processo de internacionalização. Posteriormente foi complementada por um questionário confirmatório, memorandos, comunicados, artigos de imprensa e observações. A estruturação e análise dos dados foram obtidas através de uma análise caso a caso e de cruzamento de todos os casos, seguindo as questões de investigação, as dimensões do estudo e as variáveis do modelo. A partir da análise de dados, foi observado que os participantes do estudo identificaram como estímulos importantes para o envolvimento internacional, as competências internas, o perfil do gestor e as oportunidades de mercado. Por conseguinte, verificou-se que a combinação de estímulos organizacionais e ambientais com uma natureza proactiva motivou os grupos hoteleiros portugueses a se envolverem no mercado internacional. Foi também observado, uma evolução da natureza dos estímulos motivacionais, consequência de um maior envolvimento internacional das empresas hoteleiras e evolução das condições económicas do mercado doméstico e internacional. Assim, partindo inicialmente de uma abordagem oportunista ao mercado internacional, as empresas hoteleiras portuguesas passaram a adotar uma abordagem mais sistematizada, tendo em conta a dinâmica dos mercados e as suas ambições de crescimento. Observou-se também que, nas fases iniciais de envolvimento internacional existe uma ligação entre os estímulos motivacionais e as estratégias de internacionalização. Das contribuições teóricas do trabalho destacam-se a obtenção de evidências sobre a importância, dos estímulos motivacionais no processo de internacionalização e da atitude proactiva do gestor como determinante na ligação entre as vantagens competitivas da empresa e as estratégias de internacionalização. Quanto às implicações práticas, e tendo em conta as contingências e o desenvolvimento dos mercados, destacam-se a compreensão e a importância dos recursos e competências das empresas hoteleiras na exploração das oportunidades no mercado internacional, sendo uma mais-valia para as empresas hoteleiras Portuguesas que estão a considerar expandir-se para outros mercados

Aplicação do “Performance Prism” como modelo de orientação e monitorização estratégica: um estudo de caso aplicado ao Grupo Porto Bay Hotels

JEL Classification System M100, M190Num mercado global e altamente concorrencial, a monitorização e análise integrada da performance estratégica é essencial para que as organizações atinjam os seus objectivos, alinhando as operações do dia-a-dia com a estratégia corporativa da organização. Tradicionalmente as praticas de gestão e de análise da performance são na grande maioria orientadas e baseadas em indicadores derivados de informação contabilística e financeira, limitando a leitura e análise a factos passados e com uma visão de curto prazo. Neste contexto de uma realidade actual, propomos aplicar a uma organização hoteleira em expansão um modelo de análise e medição de desempenho. Denominado de Performance Prism, o modelo defende que a monitorização da performance nas organizações deve sempre partir de objectivos estratégicos, resultado de um alinhamento entre os interesses de todos os stakeholders da empresa. Assim o Performance Prism, com uma orientação clara para os intervenientes em toda a cadeia de valor, encoraja os gestores e administração a considerar no seu processo de formulação de objectivos e de prossecução de estratégias associadas os factores de satisfação e contribuição desses mesmos stakeholders. O objectivo do trabalho será então o de estabelecer uma grelha integrada de medição da performance estratégica para o Grupo Porto Bay aplicando os princípios de Performance Prism, utilizando para isso todas as fontes de informação disponíveis na organização. Assim e utilizando o principio da não interferência com a realidade observada pretendemos, através de um processo de colecta, leitura, análise e sistematização da informação recolhida na organização, procurar explicitar como pode uma organização particular orientar a sua informação para monitorizar o seu desempenho dando assim aos gestores uma ferramenta sólida de apoio á decisão.In a demanding and global market, monitoring and analyzing strategic business performance in a continuous and integrated manner is essential for enterprises to achieve excellence, and to better align daily operations with long-term strategies. Traditionally business performance is based on financial and accounting indicators, normally focused on past actions within short term orientation. In this context we propose to apply to a hotel group called Porto Bay Hotels an integrated measurement system called Performance Prism, which highlights that performance measurement should be the result of strategic objectives defined by organization, in a way that aligns managers and stakeholders interest. The Performance Prism, with its comprehensive stakeholder orientation, encourages managers to consider the wants and needs of all the organization’s stakeholders, as well as the associated strategies, processes and capabilities. The final propose is to build for Porto Bay Hotels a guideline using the Performance Prism Model, nurturing the capabilities for monitoring strategic goals and aligning it throughout all organization levels, using and organizing all the source data and information available in this organization and therefore providing a solid management tool for decision making

Cabbage and fermented vegetables : From death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19

Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage have been associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin-converting enzyme 2 (ACE2). As a result of SARS-CoV-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT(1)R) axis associated with oxidative stress. This leads to insulin resistance as well as lung and endothelial damage, two severe outcomes of COVID-19. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most potent antioxidant in humans and can block in particular the AT(1)R axis. Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2. Fermented vegetables contain many lactobacilli, which are also potent Nrf2 activators. Three examples are: kimchi in Korea, westernized foods, and the slum paradox. It is proposed that fermented cabbage is a proof-of-concept of dietary manipulations that may enhance Nrf2-associated antioxidant effects, helpful in mitigating COVID-19 severity.Peer reviewe

Diretriz da Sociedade Brasileira de Cardiologia sobre Diagnóstico e Tratamento de Pacientes com Cardiomiopatia da Doença de Chagas

This guideline aimed to update the concepts and formulate the standards of conduct and scientific evidence that support them, regarding the diagnosis and treatment of the Cardiomyopathy of Chagas disease, with special emphasis on the rationality base that supported it.  Chagas disease in the 21st century maintains an epidemiological pattern of endemicity in 21 Latin American countries. Researchers and managers from endemic and non-endemic countries point to the need to adopt comprehensive public health policies to effectively control the interhuman transmission of T. cruzi infection, and to obtain an optimized level of care for already infected individuals, focusing on diagnostic and therapeutic opportunistic opportunities.   Pathogenic and pathophysiological mechanisms of the Cardiomyopathy of Chagas disease were revisited after in-depth updating and the notion that necrosis and fibrosis are stimulated by tissue parasitic persistence and adverse immune reaction, as fundamental mechanisms, assisted by autonomic and microvascular disorders, was well established. Some of them have recently formed potential targets of therapies.  The natural history of the acute and chronic phases was reviewed, with enhancement for oral transmission, indeterminate form and chronic syndromes. Recent meta-analyses of observational studies have estimated the risk of evolution from acute and indeterminate forms and mortality after chronic cardiomyopathy. Therapeutic approaches applicable to individuals with Indeterminate form of Chagas disease were specifically addressed. All methods to detect structural and/or functional alterations with various cardiac imaging techniques were also reviewed, with recommendations for use in various clinical scenarios. Mortality risk stratification based on the Rassi score, with recent studies of its application, was complemented by methods that detect myocardial fibrosis.  The current methodology for etiological diagnosis and the consequent implications of trypanonomic treatment deserved a comprehensive and in-depth approach. Also the treatment of patients at risk or with heart failure, arrhythmias and thromboembolic events, based on pharmacological and complementary resources, received special attention. Additional chapters supported the conducts applicable to several special contexts, including t. cruzi/HIV co-infection, risk during surgeries, in pregnant women, in the reactivation of infection after heart transplantation, and others.     Finally, two chapters of great social significance, addressing the structuring of specialized services to care for individuals with the Cardiomyopathy of Chagas disease, and reviewing the concepts of severe heart disease and its medical-labor implications completed this guideline.Esta diretriz teve como objetivo principal atualizar os conceitos e formular as normas de conduta e evidências científicas que as suportam, quanto ao diagnóstico e tratamento da CDC, com especial ênfase na base de racionalidade que a embasou. A DC no século XXI mantém padrão epidemiológico de endemicidade em 21 países da América Latina. Investigadores e gestores de países endêmicos e não endêmicos indigitam a necessidade de se adotarem políticas abrangentes, de saúde pública, para controle eficaz da transmissão inter-humanos da infecção pelo T. cruzi, e obter-se nível otimizado de atendimento aos indivíduos já infectados, com foco em oportunização diagnóstica e terapêutica. Mecanismos patogênicos e fisiopatológicos da CDC foram revisitados após atualização aprofundada e ficou bem consolidada a noção de que necrose e fibrose sejam estimuladas pela persistência parasitária tissular e reação imune adversa, como mecanismos fundamentais, coadjuvados por distúrbios autonômicos e microvasculares. Alguns deles recentemente constituíram alvos potenciais de terapêuticas. A história natural das fases aguda e crônica foi revista, com realce para a transmissão oral, a forma indeterminada e as síndromes crônicas. Metanálises recentes de estudos observacionais estimaram o risco de evolução a partir das formas aguda e indeterminada e de mortalidade após instalação da cardiomiopatia crônica. Condutas terapêuticas aplicáveis aos indivíduos com a FIDC foram abordadas especificamente. Todos os métodos para detectar alterações estruturais e/ou funcionais com variadas técnicas de imageamento cardíaco também foram revisados, com recomendações de uso nos vários cenários clínicos. Estratificação de risco de mortalidade fundamentada no escore de Rassi, com estudos recentes de sua aplicação, foi complementada por métodos que detectam fibrose miocárdica. A metodologia atual para diagnóstico etiológico e as consequentes implicações do tratamento tripanossomicida mereceram enfoque abrangente e aprofundado. Também o tratamento de pacientes em risco ou com insuficiência cardíaca, arritmias e eventos tromboembólicos, baseado em recursos farmacológicos e complementares, recebeu especial atenção. Capítulos suplementares subsidiaram as condutas aplicáveis a diversos contextos especiais, entre eles o da co-infecção por T. cruzi/HIV, risco durante cirurgias, em grávidas, na reativação da infecção após transplante cardíacos, e outros.    Por fim, dois capítulos de grande significado social, abordando a estruturação de serviços especializados para atendimento aos indivíduos com a CDC, e revisando os conceitos de cardiopatia grave e suas implicações médico-trabalhistas completaram esta diretriz.&nbsp

Nrf2-interacting nutrients and COVID-19 : time for research to develop adaptation strategies

There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPAR gamma:Peroxisome proliferator-activated receptor, NF kappa B: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2 alpha:Elongation initiation factor 2 alpha). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT(1)R axis (AT(1)R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity

Approaches in biotechnological applications of natural polymers

Natural polymers, such as gums and mucilage, are biocompatible, cheap, easily available and non-toxic materials of native origin. These polymers are increasingly preferred over synthetic materials for industrial applications due to their intrinsic properties, as well as they are considered alternative sources of raw materials since they present characteristics of sustainability, biodegradability and biosafety. As definition, gums and mucilages are polysaccharides or complex carbohydrates consisting of one or more monosaccharides or their derivatives linked in bewildering variety of linkages and structures. Natural gums are considered polysaccharides naturally occurring in varieties of plant seeds and exudates, tree or shrub exudates, seaweed extracts, fungi, bacteria, and animal sources. Water-soluble gums, also known as hydrocolloids, are considered exudates and are pathological products; therefore, they do not form a part of cell wall. On the other hand, mucilages are part of cell and physiological products. It is important to highlight that gums represent the largest amounts of polymer materials derived from plants. Gums have enormously large and broad applications in both food and non-food industries, being commonly used as thickening, binding, emulsifying, suspending, stabilizing agents and matrices for drug release in pharmaceutical and cosmetic industries. In the food industry, their gelling properties and the ability to mold edible films and coatings are extensively studied. The use of gums depends on the intrinsic properties that they provide, often at costs below those of synthetic polymers. For upgrading the value of gums, they are being processed into various forms, including the most recent nanomaterials, for various biotechnological applications. Thus, the main natural polymers including galactomannans, cellulose, chitin, agar, carrageenan, alginate, cashew gum, pectin and starch, in addition to the current researches about them are reviewed in this article.. }To the Conselho Nacional de Desenvolvimento Cientfíico e Tecnológico (CNPq) for fellowships (LCBBC and MGCC) and the Coordenação de Aperfeiçoamento de Pessoal de Nvíel Superior (CAPES) (PBSA). This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 unit, the Project RECI/BBB-EBI/0179/2012 (FCOMP-01-0124-FEDER-027462) and COMPETE 2020 (POCI-01-0145-FEDER-006684) (JAT)

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Measurement of nuclear modification factors of gamma(1S)), gamma(2S), and gamma(3S) mesons in PbPb collisions at root s(NN)=5.02 TeV

The cross sections for ϒ(1S), ϒ(2S), and ϒ(3S) production in lead-lead (PbPb) and proton-proton (pp) collisions at √sNN = 5.02 TeV have been measured using the CMS detector at the LHC. The nuclear modification factors, RAA, derived from the PbPb-to-pp ratio of yields for each state, are studied as functions of meson rapidity and transverse momentum, as well as PbPb collision centrality. The yields of all three states are found to be significantly suppressed, and compatible with a sequential ordering of the suppression, RAA(ϒ(1S)) > RAA(ϒ(2S)) > RAA(ϒ(3S)). The suppression of ϒ(1S) is larger than that seen at √sNN = 2.76 TeV, although the two are compatible within uncertainties. The upper limit on the RAA of ϒ(3S) integrated over pT, rapidity and centrality is 0.096 at 95% confidence level, which is the strongest suppression observed for a quarkonium state in heavy ion collisions to date. © 2019 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). Funded by SCOAP3.Peer reviewe

Electroweak production of two jets in association with a Z boson in proton-proton collisions root s =13 TeV

A measurement of the electroweak (EW) production of two jets in association with a Z boson in proton-proton collisions at root s = 13 TeV is presented, based on data recorded in 2016 by the CMS experiment at the LHC corresponding to an integrated luminosity of 35.9 fb(-1). The measurement is performed in the lljj final state with l including electrons and muons, and the jets j corresponding to the quarks produced in the hard interaction. The measured cross section in a kinematic region defined by invariant masses m(ll) > 50 GeV, m(jj) > 120 GeV, and transverse momenta P-Tj > 25 GeV is sigma(EW) (lljj) = 534 +/- 20 (stat) fb (syst) fb, in agreement with leading-order standard model predictions. The final state is also used to perform a search for anomalous trilinear gauge couplings. No evidence is found and limits on anomalous trilinear gauge couplings associated with dimension-six operators are given in the framework of an effective field theory. The corresponding 95% confidence level intervals are -2.6 <cwww/Lambda(2) <2.6 TeV-2 and -8.4 <cw/Lambda(2) <10.1 TeV-2. The additional jet activity of events in a signal-enriched region is also studied, and the measurements are in agreement with predictions.Peer reviewe